NALOXONE HCL

Substance Use Agent

Brand names: REZENOPY

Nasal

Mechanism of Action

12.1 Mechanism of Action Naloxone hydrochloride is an opioid antagonist that antagonizes opioid effects by competing for the same receptor sites. Naloxone hydrochloride reverses the effects of opioids, including respiratory depression, sedation, and hypotension. It can also reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.

Indications

1 INDICATIONS AND USAGE REZENOPY nasal spray is indicated for the emergency treatment of known or suspected opioid overdose

FDA Warnings

5 WARNINGS AND PRECAUTIONS Risk of Recurrent Respiratory and CNS Depression : Due to the duration of action of naloxone relative to the opioid, keep patient under continued surveillance and administer additional doses of REZENOPY nasal spray, as necessary, using a new nasal spray device while awaiting emergency medical assistance
1 ) Risk of Limited Efficacy with Partial Agonists or Mixed Agonists/Antagonists : Reversal of respiratory depression caused by partial agonists or mixed agonists/antagonists, such as buprenorphine and pentazocine, may be incomplete
3 ) Risk of Cardiovascular (CV) Effects : Abrupt postoperative reversal of opioid depression may result in adverse CV effects
1 Risk of Recurrent Respiratory and Central Nervous System Depression The duration of action of most opioids may exceed that of REZENOPY nasal spray resulting in a return of respiratory and/or central nervous system depression after an initial improvement in symptoms

Known Side Effects

7 documented side effects by frequency

Nausea

1-10%

Vomiting

1-10%

Anxiety

1-10%

Headache

0.1-1%

Drug Not Working

0.1-1%

Fatigue

0.1-1%

Insomnia

0.1-1%

Community Discussions

1 Reddit threads analysed for NALOXONE HCL

Overall Sentiment

Negative

Comparison Threads

Avg Post Score

2,299 upvotes

Most discussed side effects in community

Fatigue (1)

Rash (1)

Stomach Pain (1)

Vision Changes (1)

Cough (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

My name is Adam and I am an addict. It's been three days since I last died.

“Hi. My name is Adam and I am an addict.” The words have no meaning. Not anymore. They’ve been recited too many times. “Hello, Adam,” the chorus responded. Metal folding chairs arranged in the obligatory half-circle. The even-more obligatory stink of burned coffee mingling with stale cigarette smoke

r/nosleep2,299615y ago

Fatigue

Rash

Stomach Pain

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Compare With

6 available comparisons

Formulations

Dosage Forms

Tablet

Route

Nasal