NALOXONE HYDROCHLORIDE NASAL

Substance Use Agent

Brand names: Naloxone Hydrochloride

Nasal

Mechanism of Action

12.1 Mechanism of Action Naloxone hydrochloride is an opioid antagonist that antagonizes opioid effects by competing for the same receptor sites. Naloxone hydrochloride reverses the effects of opioids, including respiratory depression, sedation, and hypotension. It can also reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.

Indications

1 INDICATIONS AND USAGE Naloxone HCl Nasal Spray is indicated for the emergency treatment of known or suspected opioid overdose

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Risk of Recurrent Respiratory and CNS Depression : Due to the duration of action of naloxone relative to the opioid, keep patient under continued surveillance and administer repeat doses of naloxone using a new nasal spray with each dose, as necessary, while awaiting emergency medical assistance
1 ) • Risk of Limited Efficacy with Partial Agonists or Mixed Agonists/Antagonists : Reversal of respiratory depression caused by partial agonists or mixed agonists/antagonists, such as buprenorphine and pentazocine, may be incomplete
3 ) • Risk of Cardiovascular (CV) Effects : Abrupt postoperative reversal of opioid depression may result in adverse CV effects
1 Risk of Recurrent Respiratory and Central Nervous System Depression The duration of action of most opioids may exceed that of Naloxone HCl Nasal Spray resulting in a return of respiratory and/or central nervous system depression after an initial improvement in symptoms

Known Side Effects

7 documented side effects by frequency

Nausea

1-10%

Vomiting

1-10%

Anxiety

1-10%

Headache

0.1-1%

Drug Not Working

0.1-1%

Fatigue

0.1-1%

Insomnia

0.1-1%

Community Discussions

5 Reddit threads analysed for NALOXONE HYDROCHLORIDE NASAL

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

83 upvotes

Patient Experiences (r/pharmacy, r/AskDocs & more)

naloxone vending machine

So on a recent road trip in Ohio, I came across a first for me. A vending machine outside of the Men’s bathroom full of one item,Naloxone nasal spray! I’ve seen the opioid overdose kits in the restrooms (this rest area had them as well) but not a freestanding vending machine near the entrance of the

r/pharmacy3767310mo ago

Heroin overdoses tackled with naloxone nasal spray pilot in Norway

r/pharmacy23212y ago

Naloxone question for retail pharmacists

Any pharmacists selling much naloxone? How is it being sold (kits, commercial products? Is anyone selling it as a compounded nasal spray? Just looking for options since the auto-injector is crazy expensive. Thanks!

r/pharmacy12159y ago

CA naloxone without a prescription?

Hey guys, I'm a pharmacy tech at the 3 letter although not really relevant for what I'm going to ask. Like the title says, does anyone here know if you can get narcan without a prescription? My dad is going into a major surgery with a long recovery time, and even though I don't think anything will

r/pharmacy328y ago

Nasal atomizers

Hi! Does your retail pharmacy carry nasal atomizers? I am working on a naloxone order set and am unsure if traditional retail or independent pharmacies keep these in stock. If you do, is there a charge to the patient and how much? Thanks!

r/pharmacy155y ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Compare With

6 available comparisons

Formulations

Dosage Forms

Tablet

Route

Nasal