NALOXONE HYDROCHLORIDE

Substance Use Agent

Brand names: NALOXONE HYDROCHLORIDE, Narcan, Evzio

Nasal

Mechanism of Action

12.1 Mechanism of Action Naloxone hydrochloride is an opioid antagonist that antagonizes opioid effects by competing for the same receptor sites. Naloxone hydrochloride reverses the effects of opioids, including respiratory depression, sedation, and hypotension. It can also reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.

Indications

1 INDICATIONS AND USAGE Naloxone HCl Nasal Spray is indicated for the emergency treatment of known or suspected opioid overdose

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Risk of Recurrent Respiratory and CNS Depression: Due to the duration of action of naloxone relative to the opioid, keep patient under continued surveillance and administer repeat doses of naloxone using a new nasal spray with each dose, as necessary, while awaiting emergency medical assistance
1 ) • Risk of Limited Efficacy with Partial Agonists or Mixed Agonists/Antagonists: Reversal of respiratory depression caused by partial agonists or mixed agonists/antagonists, such as buprenorphine and pentazocine, may be incomplete
3 ) • Risk of Cardiovascular (CV) Effects: Abrupt postoperative reversal of opioid depression may result in adverse CV effects
1 Risk of Recurrent Respiratory and Central Nervous System Depression The duration of action of most opioids may exceed that of Naloxone HCl Nasal Spray resulting in a return of respiratory and/or central nervous system depression after an initial improvement in symptoms

Known Side Effects

7 documented side effects by frequency

Nausea

1-10%

Vomiting

1-10%

Anxiety

1-10%

Headache

0.1-1%

Drug Not Working

0.1-1%

Fatigue

0.1-1%

Insomnia

0.1-1%

Community Discussions

1 Reddit threads analysed for NALOXONE HYDROCHLORIDE

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

1,502 upvotes

Patient Experiences (r/pharmacy, r/AskDocs & more)

Free narcan in the Suzzalo vending machine

This is nothing surprising to me, although I think it’s unfortunate that kids ODing is a regular thing here.

r/udub1,502752y ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Compare With

6 available comparisons

Formulations

Dosage Forms

Tablet

Route

Nasal