NEFAZODONE HYDROCHLORIDE

Atypical Antidepressant

Brand names: Nefazodone Hydrochloride

Pregnancy: Category COral

Mechanism of Action

Pharmacodynamics The mechanism of action of nefazodone, as with other antidepressants, is unknown. Preclinical studies have shown that nefazodone inhibits neuronal uptake of serotonin and norepinephrine. Nefazodone occupies central 5-HT 2 receptors at nanomolar concentrations, and acts as an antagonist at this receptor. Nefazodone was shown to antagonize alpha 1 -adrenergic receptors, a property which may be associated with postural hypotension. In vitro binding studies showed that nefazodone ha

Indications

INDICATIONS AND USAGE Nefazodone hydrochloride tablets are indicated for the treatment of depression. When deciding among the alternative treatments available for this condition

the prescriber should consider the risk of hepatic failure associated with nefazodone hydrochloride treatment (see WARNINGS ). In many cases

loss of interest in usual activities

significant change in weight and/or appetite

insomnia or hypersomnia

psychomotor agitation or retardation

Contraindications

• CONTRAINDICATIONS Coadministration of terfenadine
• astemizole
• cisapride
• pimozide
• its inactive ingredients

FDA Warnings

Suicidality and Antidepressant Drugs Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders
Anyone considering the use of nefazodone hydrochloride tablets or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need
Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older
Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide

Known Side Effects

7 documented side effects by frequency

Depression

>10%

Drug Not Working

1-10%

Insomnia

1-10%

Anxiety

1-10%

Nausea

1-10%

Headache

0.1-1%

Weight Loss

0.1-1%

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Compare With

7 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral