OCTREOTIDE ACETATE

Other

Brand names: Octreotide Acetate

Intravenous, Subcutaneous

Mechanism of Action

12.1 Mechanism of Action Octreotide acetate injection exerts pharmacologic actions similar to the natural hormone, somatostatin. It is an even more potent inhibitor of GH, glucagon, and insulin than somatostatin. Like somatostatin, it also suppresses luteinizing hormone (LH) response to gonadotropin releasing hormone (GnRH), decreases splanchnic blood flow, and inhibits release of serotonin, gastrin, VIP, secretin, motilin, and pancreatic polypeptide. By virtue of these pharmacological actions, octreotide has been used to treat the symptoms associated with metastatic carcinoid tumors (flushing and diarrhea), and VIP secreting adenomas (watery diarrhea).

Indications

1 INDICATIONS AND USAGE Octreotide Acetate Injection is a somatostatin analogue indicated: Acromegaly : To reduce blood levels of growth hormone (GH) and insulin growth factor-1 (IGF-1

somatomedin C) in acromegaly patients who have had inadequate response to or cannot be treated with surgical resection

pituitary irradiation

or reduction in tumor size or rate of growth

were not shown in clinical trials performed with Octreotide Acetate Injection

somatomedin C) in acromegaly patients who have had inadequate response to or cannot be treated with surgical resection

Contraindications

• 4 CONTRAINDICATIONS Sensitivity to this drug or any of its components. Sensitivity to this drug or any of its components. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Cardiac Function Abnormalities : Increased risk for higher degree of atrioventricular blocks
Use with caution in at-risk patients
1 Cardiac Function Abnormalities Complete Atrioventricular Block Patients who receive octreotide acetate injection intravenously may be at increased risk for higher degree atrioventricular blocks
Severe hyperglycemia, subsequent pneumonia, and death following initiation of octreotide acetate injection therapy was reported in one patient with no history of hyperglycemia

Known Side Effects

10 documented side effects by frequency

Diarrhea

>10%

Fatigue

1-10%

General Unwellness

1-10%

High Blood Pressure

1-10%

Nausea

1-10%

Abdominal Pain

1-10%

Weakness

1-10%

Weight Loss

1-10%

Injection Site Pain

1-10%

Headache

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Intravenous, Subcutaneous