OLANZAPINE PAMOATE

Atypical Antipsychotic

Brand names: ZYPREXA Relprevv

Intramuscular

Mechanism of Action

12.1 Mechanism of Action The mechanism of action of olanzapine, in the listed indications is unclear. However, the efficacy of olanzapine in schizophrenia could be mediated through a combination of dopamine and serotonin type 2 (5HT 2 ) antagonism.

Indications

the prescriber

healthcare facility

patient

and pharmacy must all be enrolled in the ZYPREXA RELPREVV Patient Care Program. To enroll

Contraindications

• 4 CONTRAINDICATIONS None. None.

FDA Warnings

5 WARNINGS AND PRECAUTIONS Elderly Patients with Dementia-Related Psychosis: Increased risk of death and increased incidence of cerebrovascular adverse events (e
3 ) Suicide: The possibility of a suicide attempt is inherent in schizophrenia, and close supervision of high-risk patients should accompany drug therapy
7 ) Hyperglycemia and Diabetes Mellitus: In some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, has been reported in patients taking olanzapine
1 Post-Injection Delirium/Sedation Syndrome During premarketing clinical studies of ZYPREXA RELPREVV, adverse events that presented with signs and symptoms consistent with olanzapine overdose, in particular, sedation (including coma) and/or delirium, were reported in patients following an injection of ZYPREXA RELPREVV [see Boxed Warning and Dosage and Administration ( 2

Known Side Effects

8 documented side effects by frequency

Drug Not Working

>10%

Weight Gain

>10%

Drowsiness

1-10%

Nausea

1-10%

Fatigue

1-10%

Anxiety

1-10%

Vomiting

1-10%

Condition Worsened

0.1-1%

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Compare With

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Formulations

Dosage Forms

Tablet

Route

Intramuscular