OLMESARTAN MEDOXOMIL AMLODIPINE AND HYDROCHLOROTHIAZIDE

Thiazide Diuretic

Brand names: Olmesartan medoxomil Amlodipine and Hydrochlorothiazide

Oral

Mechanism of Action

12.1 Mechanism of Action The active ingredients of olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets target three separate mechanisms involved in blood pressure regulation. Specifically, amlodipine blocks the contractile effects of calcium on cardiac and vascular smooth muscle cells; olmesartan medoxomil blocks the vasoconstriction and sodium retaining effects of angiotensin II on cardiac, vascular smooth muscle, adrenal and renal cells; and hydrochlorothiazide directly promotes the excretion of sodium and chloride in the kidney leading to reductions in intravascular volume. For a more detailed description of the mechanisms of action for each individual component, see below. Olmesartan medoxomil. Angiotensin II is formed from angiotensin I in a reaction catalyzed by ACE, kininase II. Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimul

Indications

1 INDICATIONS AND USAGE Olmesartan medoxomil

amlodipine and hydrochlorothiazide tablets are indicated for the treatment of hypertension

alone or with other antihypertensive agents

to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular (CV) events

amlodipine and hydrochlorothiazide tablets. Control of high blood pressure should be part of comprehensive cardiovascular risk management

including

Contraindications

• 4 CONTRAINDICATIONS Because of the hydrochlorothiazide component
• olmesartan medoxomil
• amlodipine and hydrochlorothiazide tablets are contraindicated in patients with anuria
• hypersensitivity to any component
• or hypersensitivity to other sulfonamide-derived drugs. Do not co-administer aliskiren with olmesartan medoxomil

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Hypotension: Correct volume or salt depletion prior to administration
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death
Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death
, patients with severe congestive heart failure), treatment with ACE inhibitors and angiotensin receptor antagonists has been associated with oliguria or progressive azotemia and (rarely) with acute renal failure and/or death

Known Side Effects

11 documented side effects by frequency

Diarrhea

1-10%

Weight Loss

1-10%

Dizziness

1-10%

Nausea

1-10%

Drug Not Working

1-10%

Fatigue

1-10%

Headache

1-10%

Constipation

0.1-1%

Low Blood Pressure

0.1-1%

Shortness of Breath

0.1-1%

Vomiting

0.1-1%

Community Discussions

3 Reddit threads analysed for OLMESARTAN MEDOXOMIL AMLODIPINE AND HYDROCHLOROTHIAZIDE

Overall Sentiment

Slightly positive

Comparison Threads

Avg Post Score

560 upvotes

Most discussed side effects in community

Diarrhea (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

Update on my screaming grayby Smudge (15)

I posted a few months ago about my deaf senior foster kitty Smudge and his love of yowling into the wee hours of the morning, and got a lot of good advice (and Smudge appreciation!) from the post. After multiple vet visits about both the nighttime yelling AND intermittent but worsening diarrhea, I f

r/seniorkitties952351y ago

Diarrhea

Reminder to check your receipts @ Watsons

Please check your receipts bago umalis ng store, kahit anong store. Aminado ako na kasalanan ko dahil di ko chineck pero in my defense, may hinahabol kasi akong appointment nun. Sa Watsons Eastwood pala to. Pag-uwi ko nalang nakita na may nacharge sa akin na amlodipine? To my understanding, mainten

r/CasualPH3681023mo ago

Common blood pressure drug shows promise for treating ADHD symptoms. In experiments using animal models and human geneti…

r/psychology3605712mo ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

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Formulations

Dosage Forms

Tablet

Route

Oral