OLMESARTAN MEDOXOMIL

Other

Brand names: Olmesartan Medoxomil

Oral

Mechanism of Action

12.1 Mechanism of Action Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation and renal reabsorption of sodium. Olmesartan blocks the vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in vascular smooth muscle. Its action is, therefore, independent of the pathways for angiotensin II synthesis. An AT2 receptor is found also in many tissues, but this receptor is not known to be associated with cardiovascular homeostasis. Olmesartan has more than a 12,500-fold greater affinity for the AT1 receptor than for the AT2 receptor. Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin I, is a mechani

Indications

1 INDICATIONS & USAGE Olmesartan medoxomil tablets are indicated for the treatment of hypertension in adults and children six years of age and older

to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events

including

as appropriate

lipid control

diabetes management

FDA Warnings

5 WARNINGS AND PRECAUTIONS · Avoid fetal (in utero) exposure ( 5
Use of drugs that act on the renin-angiotensin system (RAS) during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death
Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death
, patients with severe congestive heart failure), treatment with angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor antagonists has been associated with oliguria and/or progressive azotemia and rarely with acute renal failure and/or death

Known Side Effects

11 documented side effects by frequency

Diarrhea

1-10%

Weight Loss

1-10%

Dizziness

1-10%

Nausea

1-10%

Drug Not Working

1-10%

Fatigue

1-10%

Headache

1-10%

Constipation

0.1-1%

Low Blood Pressure

0.1-1%

Shortness of Breath

0.1-1%

Vomiting

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral