OLODATEROL RESPIMAT INHALATION SPRAY

Beta-2 Agonist Bronchodilator

Brand names: Striverdi Respimat

Respiratory (inhalation)

Mechanism of Action

12.1 Mechanism of Action Olodaterol is a long-acting beta 2 -adrenergic agonist (LABA). The compound exerts its pharmacological effects by binding and activation of beta 2 -adrenoceptors after topical administration by inhalation. Activation of these receptors in the airways results in a stimulation of intracellular adenyl cyclase, an enzyme that mediates the synthesis of cyclic-3', 5' adenosine monophosphate (cAMP). Elevated levels of cAMP induce bronchodilation by relaxation of airway smooth muscle cells. In vitro studies have shown that olodaterol has 241-fold greater agonist activity at beta 2 -adrenoceptors compared to beta 1 -adrenoceptors and 2,299-fold greater agonist activity compared to beta 3 -adrenoceptors. The clinical significance of these findings is unknown. Beta-adrenoceptors are divided into three subtypes: beta 1 -adrenoceptors predominantly expressed on cardiac smooth muscle, beta 2 -adrenoceptors predominantly expressed on airway smooth muscle, and beta 3 -adrenoce

Indications

1 INDICATIONS AND USAGE STRIVERDI RESPIMAT Inhalation Spray is a long-acting beta 2 -adrenergic agonist (LABA) indicated for: The long-term

once-daily maintenance bronchodilator treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD)

Contraindications

• 4 CONTRAINDICATIONS Use of a LABA
• including STRIVERDI RESPIMAT
• without an inhaled corticosteroid is contraindicated in patients with asthma [see Warnings and Precautions (5.1) ] . STRIVERDI RESPIMAT is not indicated for the treatment of asthma. Use of a LABA
• including STRIVERDI RESPIMAT
• without an inhaled corticosteroid is contraindicated in patients with asthma. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS LABA as monotherapy (without an inhaled corticosteroid) for asthma increases the risk of serious asthma-related events
Excessive use of STRIVERDI RESPIMAT, or use in conjunction with other medications containing LABA can result in clinically significant cardiovascular effects and may be fatal
1 Serious Asthma-Related Events – Hospitalizations, Intubations, Death The safety and efficacy of STRIVERDI RESPIMAT in patients with asthma have not been established
Use of long-acting beta 2 -adrenergic agonists (LABA) as monotherapy [without inhaled corticosteroids (ICS)] for asthma is associated with an increased risk of asthma-related death

Known Side Effects

9 documented side effects by frequency

Shortness of Breath

>10%

Cough

>10%

Drug Not Working

1-10%

Fatigue

1-10%

Headache

1-10%

Diarrhea

1-10%

Dizziness

0.1-1%

Nausea

0.1-1%

Falls

0.1-1%

Community Discussions

2 Reddit threads analysed for OLODATEROL RESPIMAT INHALATION SPRAY

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

12 upvotes

Patient Experiences (r/pharmacy, r/AskDocs & more)

Spiriva Respimat Dosing Question

Hello all, I'm working on updating my hospital's formulary and I have a question about Spiriva Respimat dosing for both COPD and asthma. My drug references (namely Lexicomp and Micromedex) say to give 2 inhalations of the 1.25 mcg Respimat for asthma and 2 inhalations of the 2.5 mcg Respimat for COP

r/pharmacy2252y ago

Did Teva Recently Change Anything on Pro-Air Inhalers?

I just got a refill on my Pro-Air rescue inhaler. I've been using them for years. When I was priming it, I noticed that the medication seemed to be spraying out a lot more forcibly, comparable to the old ozone destroying CFC Albuterol inhalers. Am I just seeing things, or did the manufacturer recent

r/pharmacy1913y ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

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Formulations

Dosage Forms

Tablet

Route

Respiratory (inhalation)