OMEGA-3-ACID ETHYL ESTERS

Other

Brand names: Omega-3-acid ethyl esters

Oral

Mechanism of Action

12.1 Mechanism of Action The mechanism of action of omega-3-acid ethyl esters is not completely understood. Potential mechanisms of action include inhibition of acyl-CoA:1,2-diacylglycerol acyltransferase, increased mitochondrial and peroxisomal β-oxidation in the liver, decreased lipogenesis in the liver, and increased plasma lipoprotein lipase activity. Omega-3-acid ethyl esters may reduce the synthesis of TG in the liver because EPA and DHA are poor substrates for the enzymes responsible for TG synthesis, and EPA and DHA inhibit esterification of other fatty acids.

Indications

exercise

weight loss in obese patients

thiazides

estrogens) should be discontinued or changed

if possible

principally eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)

Contraindications

• 4 CONTRAINDICATIONS Omega-3-acid ethyl esters capsules are contraindicated in patients with known hypersensitivity (e.g.
• anaphylactic reaction) to omega-3-acid ethyl esters or any of its components. Omega-3-acid ethyl esters capsules are contraindicated in patients with known hypersensitivity (e.g.
• anaphylactic reaction) to omega-3-acid ethyl esters or any of its components.

FDA Warnings

5 WARNINGS AND PRECAUTIONS In patients with hepatic impairment, monitor ALT and AST levels periodically during therapy
It is not known whether patients with allergies to fish and/or shellfish, are at increased risk of an allergic reaction to omega-3-acid ethyl esters

Known Side Effects

12 documented side effects by frequency

Nausea

1-10%

Fatigue

1-10%

Drug Not Working

1-10%

Diarrhea

1-10%

Headache

1-10%

Itching

1-10%

Dizziness

1-10%

Shortness of Breath

1-10%

Joint Pain

0.1-1%

Limb Pain

0.1-1%

General Unwellness

0.1-1%

Weakness

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral