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Brand names: Ondansetron
12.1 Mechanism of Action Ondansetron is a selective 5-HT 3 receptor antagonist. While its mechanism of action has not been fully characterized, ondansetron is not a dopamine-receptor antagonist. Serotonin receptors of the 5-HT 3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. It is not certain whether ondansetron’s antiemetic action is mediated centrally, peripherally, or in both sites. However, cytotoxic chemotherapy appears to be associated with release of serotonin from the enterochromaffin cells of the small intestine. In humans, urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion increases after cisplatin administration in parallel with the onset of emesis. The released serotonin may stimulate the vagal afferents through the 5-HT 3 receptors and initiate the vomiting reflex.
Contraindications
10 documented side effects by frequency
1 Reddit threads analysed for ONDANSETRON TABLETS
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
109 upvotes
This past week my pharmacy received what I can only describe as 2 AI phone calls attempting to mimic a human voice. The voice for both were identical - it wasn’t like an automated voicemail robot or directory system. At first listen it sounds like a man, but it left me feeling extremely unsettled. I
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5 available comparisons
Dosage Forms
Tablet
Route
Oral