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Brand names: Ondansetron, Zofran
12.1 Mechanism of Action Ondansetron is a selective 5‑HT 3 receptor antagonist. While its mechanism of action has not been fully characterized, ondansetron is not a dopamine‑receptor antagonist. Serotonin receptors of the 5‑HT 3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. It is not certain whether ondansetron’s antiemetic action is mediated centrally, peripherally, or in both sites. However, cytotoxic chemotherapy appears to be associated with release of serotonin from the enterochromaffin cells of the small intestine. In humans, urinary 5‑hydroxyindoleacetic acid (5‑HIAA) excretion increases after cisplatin administration in parallel with the onset of emesis. The released serotonin may stimulate the vagal afferents through the 5‑HT 3 receptors and initiate the vomiting reflex.
Contraindications
10 documented side effects by frequency
15 Reddit threads analysed for ONDANSETRON
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
18 upvotes
Most discussed side effects in community
(I apologise if and when the formatting looks terrible. Still figuring mobile out) Hi guys. I noticed this sub doesn't have an existing archive of products or supplements for treating IBS. Information can be difficult to obtain and new medicine and products often go unnoticed so let's gather it
Hello everyone, More people than I expected were after my honest experience of the GERD surgery! That is excellent and I wish good luck to anyone going for it... Anyway... The surgery stared with two needles, one local anaesthetic and one I.V to administer the drugs, both of which were basically pai
I had absolutely debilitating digestive problems for years (given the IBS diagnosis of exclusion). I went to all of the “top GI docs'' and they had NO answers. They said we don’t know what’s wrong with you. One even told me it was all in my head. Take pill, drink water, eat fiber, take probiotics, e
**FIRST-LINE THERAPY** In terms of medical therapy, the usual approach has been to start an antispasmodic together with a laxative or an antidiarrhoeal depending on the predominant bowel pattern. Antispasmodics in general and specifically hyoscine and peppermint oil have been shown to improve IBS
Hello fellow IBSers, Before I start with this large pile of info I am about to drop, I am going to say that I AM NOT A DOCTOR OR ANY SORT OF MEDICAL PROFESSIONAL. Everything here is from my personal journal I wrote down and experience so your results/symptoms could differ with everyone else. I will
Hi so I bought a course of symprove which is about three months worth. I’m roughly 2/3 of the way through this and thought I’d share my review of how I’ve found it. For context, I have IBS-D, post infectious since two years ago. Diet tends to not really affect my symptoms (I’ve tried most if not al
Been suffering Nausea since April. Had an endoscopy found i only had very mild acid reflux. Been on more than 4 kinds of anti emetics which never helped alleviate the nausea (ondansetron, metroclopromide, motillium, even some vertigo medication). My doctor just keeps changing my medication so i’m
hi friends... its currently 2 am and I am having a bit of an anxiety episode. to start, im 19 and a girl. starting about 3 weeks ago i got random nausea and heart burn every day and my parents nonstop said I was either sick or it was a diet issue. I ended up begging for them to take me to the ER, an
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
10 available comparisons
Dosage Forms
Tablet
Route
Oral