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Brand names: TAGRISSO, Tagrisso
12.1 Mechanism of Action Osimertinib is a kinase inhibitor of the epidermal growth factor receptor (EGFR), which binds irreversibly to certain mutant forms of EGFR (T790M, L858R, and exon 19 deletions) at approximately 9-fold lower concentrations than wild-type. Two pharmacologically-active metabolites (AZ7550 and AZ5104 circulating at approximately 10% of the parent) with similar inhibitory profiles to osimertinib have been identified in the plasma after oral administration of osimertinib. AZ7550 showed a similar potency to osimertinib, while AZ5104 showed greater potency against exon 19 deletion and T790M mutants (approximately 8-fold) and wild-type (approximately 15-fold) EGFR. In vitro , osimertinib also inhibited the activity of HER2, HER3, HER4, ACK1, and BLK at clinically relevant concentrations. In cultured cells and animal tumor implantation models, osimertinib exhibited anti-tumor activity against NSCLC lines harboring EGFR-mutations (T790M/L858R, L858R, T790M/exon 19 deletio
Contraindications
8 documented side effects by frequency
9 Reddit threads analysed for OSIMERTINIB
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
16 upvotes
Most discussed side effects in community
Hi Everyone, I didn't find any India specific cancer sub, so posting it here. My mother has stage 4-a lung cancer. There is some mutation called EGFR which is present in her case so doctor has suggested a medicine(Osimertinib) based on that and we are continuing this for past 2 months now. PET scan
Two weeks ago, my dad was diagnosed with Stage IV EGFR-mutated NSCLC (adenocarcinoma) with brain metastases. It’s been an emotional marathon ever since—the news came out of nowhere. He didn’t show any typical symptoms of cancer. The only noticeable changes were that he had been more forgetful than u
Welcome back to this week's newsflash 1. The role of fiber in an IBD diet is complex. An expert explains why not all fiber is bad for UC patients and how the type of fiber and disease stage are crucial factors. Do you want to know [more](https://www.onlymyhealth.com/should-people-with-ulcerative-col
My wife was diagnosed with stage four adenocarcinoma lung cancer. Prescribed Tarceva (erlotinib), and she improved for a year, then started to decline. Nearly two years after diagnosis - and getting worse - doctor decides she is a candidate for Tagrisso. What a difference. Within two weeks of starti
My dad (62) was diagnosed with stage 4 lung adenocarcinoma last week. It’s spread to his bones, both lungs, and lymph nodes. He has an EGFR L861Q mutation - which I’ve learned is uncommon and has less data than the typical EGFR mutations. Starting osimertinib this week. We’re in Pakistan, getting ca
On here again looking for input from this incredible group of people. My mom was diagnosed with stage IV adenocarcinoma with the EGFR mutation this past summer. She has shown progression on her first line of treatment (Osimertinib)and is slated to start chemotherapy next week as we wait for new biom
Hi everyone, A few weeks ago, I posted here asking how long it usually takes to receive a treatment plan. Today, we finally got one from the oncologist: my sister has EGFR exon 19 deletion (90%) and PD-L1 30%, and she’ll be starting Targiso (osimertinib) in a week or two. For those who’ve had simila
Am now scheduled to give a 15 minute presentation in my on-site interview for a general PGY1 residency in the West Coast. Topic can either be patient case or one of my choosing. Because this residency is fairly generic with maybe more of an admin/project management focus (8 weeks in ED med rec, 1
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Dosage Forms
Tablet
Route
Oral