Brand names: Oxcarbazepine, Trileptal
12.1 Mechanism of Action The pharmacological activity of oxcarbazepine is primarily exerted through the 10-monohydroxy metabolite (MHD) of oxcarbazepine [see Clinical Pharmacology ( 12.3 )]. The precise mechanism by which oxcarbazepine and MHD exert their anti-seizure effect is unknown; however, in vitro electrophysiological studies indicate that they produce blockade of voltage-sensitive sodium channels, resulting in stabilization of hyperexcited neural membranes, inhibition of repetitive neuronal firing, and diminution of propagation of synaptic impulses. These actions are thought to be important in the prevention of seizure spread in the intact brain. In addition, increased potassium conductance and modulation of high-voltage activated calcium channels may contribute to the anticonvulsant effects of the drug. No significant interactions of oxcarbazepine or MHD with brain neurotransmitter or modulator receptor sites have been demonstrated.
Contraindications
10 documented side effects by frequency
7 Reddit threads analysed for OXCARBAZEPINE
Overall Sentiment
Slightly positive
Comparison Threads
0
Avg Post Score
59 upvotes
Most discussed side effects in community
[Original Post ](https://www.reddit.com/r/beyondthebump/comments/1gtneeo/baby_had_seizures_at_15_weeks_old_still/) First, thank you to everyone for your kind words on my previous post. We have some potential answers now, so I thought I'd share an update. \*\* **Please Note**: Everything stated belo
Hey all, I’ve been on this sub for a while now and I’ve noticed that almost every mention of Keppra is a negative one. However, my experience with the drug has been very good and I’d like to share it. I was diagnosed with juvenile myoclonic epilepsy fifteen years ago. For the first few years I was o
All I see, are horrible stories about Keppra — I’m not sure if I’ve seen or heard from anyone with a positive experience. Is there any body out there that likes it?!? Tell me about it, please? I think I’m going on it soon…. I’ve (42m w/ TLE) just recently switched from carbamazepine to oxcarbazepin
So a while back I asked people on different online groups for questions for Dr. Zeidman. He very kindly wrote back a few days ago and here are the questions, with his resposnes. **Questions about Treatments** 1. Can IVIG still potentially help those without the specific antibodies in your study? For
**Welcome back to SAR!** Ahh May—the grass is coming back, the birds are yelling in the morning, and it's Borderline Personality Disorder Awareness Month! Oh what a coincidence, that’s our topic for today! This week we also feature **Alex (**u/smokeytaboo477), a 24 year old American diagnosed with
Hello. I just wanted to share my experience with overcoming grand mal seizures. As soon as I graduated from High School, I started having seizures when I was 19 years old. All I can remember was having that aura (dejavu sickly feeling) and waking up in a hospital numerous times. My license was susp
Hello fellow pharmacists! Due to USP <800>, we have to crush hazardous meds (warfarin, finasteride, oxcarbazepine, etc.) that are administered via feeding tube in the chemo hood. However, no one seems to know what BUD to give to the final product. The BUD I’ve seen ranges anywhere from 30 days
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25 available comparisons
Dosage Forms
Tablet
Route
Oral