OXYCODONE AND ASPIRIN

Opioid Analgesic

Brand names: Oxycodone and Aspirin

Oral

Mechanism of Action

Mechanism of Action Oxycodone is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of oxycodone is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with oxycodone. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression. The precise mechanism of the analgesic action of oxycodone is unknown. However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and are thought to play a role in the analgesic effects of this drug. Aspirin (acetylsalicylic acid) works by inhibiting the body’s production of prostaglandins, including prostaglandins involved in inflammation. Prostaglandins cause pain sensations by stimulating muscle contractions and dilating blood vessels th

Indications

abuse

and misuse

with opioids

which can occur at any dosage or duration (see WARNINGS )

reserve oxycodone and aspirin tablets for use in patients for whom alternative treatment options (e.g.

non-opioid analgesics) • Have not been tolerated

Contraindications

• including paralytic ileus (see WARNINGS ) • Hypersensitivity to oxycodone or aspirin
• (e.g. angioedema) (see WARNINGS ) • Patients with hemophilia. • Aspirin should not be used in children or teenagers for viral infections
• with or without fever
• because of the risk of Reye syndrome (see WARNINGS )

FDA Warnings

WARNING: SERIOUS AND LIFE-THREATENING RISKS FROM USE OF OXYCODONE AND ASPIRIN TABLETS Addiction, Abuse, and Misuse Because the use of oxycodone and aspirin tablets exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death, assess each patient’s risk prior to prescribing and reassess all patients regularly for the development of these behaviors and conditions (see WARNINGS )
Life-Threatening Respiratory Depression Serious, life-threatening, or fatal respiratory depression may occur with use of oxycodone and aspirin tablets, especially during initiation or following a dosage increase
To reduce the risk of respiratory depression, proper dosing and titration of oxycodone and aspirin tablets are essential (see WARNINGS )
Accidental Ingestion Accidental ingestion of even one dose of oxycodone and aspirin tablets, especially by children, can result in a fatal overdose of oxycodone (see WARNINGS )

Known Side Effects

7 documented side effects by frequency

Nausea

0.1-1%

Drug Not Working

0.1-1%

Fatigue

0.1-1%

Diarrhea

0.1-1%

Vomiting

0.1-1%

Anxiety

0.1-1%

Depression

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral