OXYCODONE HYDROCHLORIDE ORAL SOLUTION

Opioid Analgesic

Brand names: Oxycodone Hydrochloride Oral Solution

Oral

Mechanism of Action

12.1 Mechanism of Action Oxycodone is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of oxycodone is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with oxycodone. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression. The precise mechanism of the analgesic action is unknown. However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and are thought to play a role in the analgesic effects of this drug.

Indications

abuse

and misuse with opioids

even at recommended doses

[see Warnings and Precautions (5.2) ]

reserve Oxycodone Hydrochloride Oral Solution for use in patients for whom alternative treatment options [e.g.

non-opioid analgesics or opioid combination products] • Have not been tolerated or are not expected to be tolerated

Contraindications

• including paralytic ileus [see Warnings and Precautions (5.12)] • Hypersensitivity to oxycodone (e.g.
• including paralytic ileus. (4) • Hypersensitivity to oxycodone. (4)

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Life-Threatening Respiratory Depression in Patients with Chronic Pulmonary Disease or in Elderly, Cachectic, or Debilitated Patients: Monitor closely, particularly during initiation and titration
10) • Risks of Use in Patients with Increased Intracranial Pressure, Brain Tumors, Head Injury, or Impaired Consciousness: Monitor for sedation and respiratory depression
1 Risk of Accidental Overdose and Death due to Medication Errors Dosing errors can result in accidental overdose and death
As an opioid, Oxycodone Hydrochloride Oral Solution exposes users to the risks of addiction, abuse, and misuse [see Drug Abuse and Dependence (9) ]

Known Side Effects

7 documented side effects by frequency

Nausea

0.1-1%

Drug Not Working

0.1-1%

Fatigue

0.1-1%

Diarrhea

0.1-1%

Vomiting

0.1-1%

Anxiety

0.1-1%

Depression

0.1-1%

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Compare With

17 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral