PACLITAXEL PROTEIN-BOUND PARTICLES

Chemotherapy

Brand names: Paclitaxel protein-bound particles

Intravenous

Mechanism of Action

12.1 Mechanism of Action Paclitaxel is a microtubule inhibitor that promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. Paclitaxel induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis.

Indications

1 INDICATIONS AND USAGE Paclitaxel is a microtubule inhibitor indicated for the treatment of: Metastatic breast cancer

as first-line treatment in combination with carboplatin

in patients who are not candidates for curative surgery or radiation therapy. ( 1.2 ) Metastatic adenocarcinoma of the pancreas as first-line treatment

in combination with carboplatin

in combination with gemcitabine.

Contraindications

• 4 CONTRAINDICATIONS Paclitaxel protein-bound particles for injectable suspension (albumin-bound) is contraindicated in patients with: Baseline neutrophil counts of < 1
• 500 cells/mm 3 . ( 4 ) Severe hypersensitivity reactions to paclitaxel. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Sensory neuropathy occurs frequently and may require dose reduction or treatment interruption
4 ) Severe hypersensitivity reactions with fatal outcome have been reported
6 ) Paclitaxel protein-bound particles for injectable suspension (albumin-bound) contains albumin derived from human blood, which has a theoretical risk of viral transmission
Advise patients of potential risk to a fetus and to use effective contraception

Known Side Effects

6 documented side effects by frequency

Nausea

1-10%

Diarrhea

1-10%

Shortness of Breath

1-10%

Fatigue

1-10%

Fever

1-10%

Vomiting

1-10%

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Compare With

14 available comparisons

Formulations

Dosage Forms

Tablet

Route

Intravenous