PALIPERIDONE

Atypical Antipsychotic

Brand names: Paliperidone, Invega

Oral

Mechanism of Action

12.1 Mechanism of Action Paliperidone is the major active metabolite of risperidone. The mechanism of action of paliperidone in schizophrenia is unclear. However, the drug's therapeutic effect in schizophrenia could be mediated through a combination of central dopamine Type 2 (D 2 ) and serotonin Type 2 (5HT 2A ) receptor antagonism.

Indications

as well as one maintenance trial in adults.

Contraindications

• 4 CONTRAINDICATIONS Paliperidone extended-release tablets are contraindicated in patients with a known hypersensitivity to either paliperidone or risperidone
• or to any of the excipients in the paliperidone extended-release tablet formulation. Hypersensitivity reactions
• including anaphylactic reactions and angioedema
• have been reported in patients treated with risperidone and in patients treated with paliperidone. Paliperidone is a metabolite of risperidone. Known hypersensitivity to paliperidone
• risperidone

FDA Warnings

5 WARNINGS AND PRECAUTIONS Cerebrovascular Adverse Reactions: An increased incidence of cerebrovascular adverse reactions (e
, stroke, transient ischemic attack, including fatalities) has been seen in elderly patients with dementia-related psychoses treated with atypical antipsychotics
3) QT Prolongation: Increase in QT interval, avoid use with drugs that also increase QT interval and in patients with risk factors for prolonged QT interval
5) Metabolic Changes: Atypical antipsychotic drugs have been associated with metabolic changes that may increase cardiovascular/cerebrovascular risk

Known Side Effects

3 documented side effects by frequency

Drug Not Working

>10%

Weight Gain

1-10%

Condition Worsened

0.1-1%

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Compare With

19 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral