PEGFLILGRASTIM-FPGK

Other

Brand names: STIMUFEND

Subcutaneous

Mechanism of Action

12.1 Mechanism of Action Pegfilgrastim products are colony-stimulating factors that act on hematopoietic cells by binding to specific cell surface receptors, thereby stimulating proliferation, differentiation, commitment, and end cell functional activation.

Indications

1 INDICATIONS AND USAGE Stimufend is a leukocyte growth factor indicated to decrease the incidence of infection

as manifested by febrile neutropenia

FDA Warnings

5 WARNINGS AND PRECAUTIONS Fatal splenic rupture: Evaluate patients who report left upper abdominal or shoulder pain for an enlarged spleen or splenic rupture
2 ) Serious allergic reactions, including anaphylaxis: Permanently discontinue Stimufend in patients with serious allergic reactions
3 ) Fatal sickle cell crises: Discontinue Stimufend if sickle cell crisis occurs
1 Splenic Rupture Splenic rupture, including fatal cases, can occur following the administration of pegfilgrastim products

Known Side Effects

3 documented side effects by frequency

Diarrhea

>10%

Shortness of Breath

>10%

Nausea

>10%

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Formulations

Dosage Forms

Tablet

Route

Subcutaneous