PILOCARPINE HYDROCHLORIDE

Electrolyte / Mineral

Brand names: Pilocarpine Hydrochloride

Pregnancy: Category COral

Mechanism of Action

Pharmacodynamics: Pilocarpine is a cholinergic parasympathomimetic agent exerting a broad spectrum of pharmacologic effects with predominant muscarinic action. Pilocarpine, in appropriate dosage, can increase secretion by the exocrine glands. The sweat, salivary, lacrimal, gastric, pancreatic, and intestinal glands and the mucous cells of the respiratory tract may be stimulated. When applied topically to the eye as a single dose it causes miosis, spasm of accommodation, and may cause a transitor

Indications

INDICATIONS AND USAGE: Pilocarpine hydrochloride tablets

USP are indicated for 1) the treatment of symptoms of dry mouth from salivary gland hypofunction caused by radiotherapy for cancer of the head and neck

and 2) the treatment of symptoms of dry mouth in patients with Sjogren's syndrome.

Contraindications

• CONTRAINDICATIONS: Pilocarpine hydrochloride tablets are contraindicated in patients with uncontrolled asthma
• known hypersensitivity to pilocarpine
• and when miosis is undesirable
• e.g.
• in acute iritis and in narrow-angle (angle closure) glaucoma.

FDA Warnings

WARNINGS: Cardiovascular Disease: Patients with significant cardiovascular disease may be unable to compensate for transient changes in hemodynamics or rhythm induced by pilocarpine

Known Side Effects

10 documented side effects by frequency

Drug Not Working

>10%

Headache

>10%

Blurred Vision

1-10%

Nausea

1-10%

Fatigue

1-10%

Dizziness

1-10%

Shortness of Breath

0.1-1%

Joint Pain

0.1-1%

Falls

0.1-1%

Diarrhea

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral