PIPERACILLIN SODIUM

Penicillin Antibiotic

Brand names: Piperacillin and Tazobactam

Intravenous

12.1 Mechanism of Action Piperacillin and tazobactam for injection is an antibacterial drug [ see Microbiology ( 12.4 ) ].

1 INDICATIONS AND USAGE Piperacillin and tazobactam for injection is a combination of piperacillin

a penicillin-class antibacterial and tazobactam

B. ovatus

B. thetaiotaomicron

Haemophilus influenzae

Klebsiella pneumoniae

Contraindications

• 4 CONTRAINDICATIONS Piperacillin and tazobactam for injection is contraindicated in patients with a history of allergic reactions to any of the penicillins
• cephalosporins
• or beta-lactamase inhibitors. Patients with a history of allergic reactions to any of the penicillins
• cephalosporins
• or beta-lactamase inhibitors. ( 4 )

5 WARNINGS AND PRECAUTIONS • Serious hypersensitivity reactions (anaphylactic/anaphylactoid) have been reported in patients receiving piperacillin and tazobactam for injection
Patients receiving higher doses, especially in the presence of renal impairment may be at greater risk
5 ) • Nephrotoxicity in critically ill patients has been observed; the use of piperacillin and tazobactam for injection was found to be an independent risk factor for renal failure and was associated with delayed recovery of renal function as compared to other beta-lactam antibacterial drugs in a randomized, multicenter, controlled trial in critically ill patients
1 Hypersensitivity Adverse Reactions Serious and occasionally fatal hypersensitivity (anaphylactic/anaphylactoid) reactions (including shock) have been reported in patients receiving therapy with piperacillin and tazobactam for injection

8 documented side effects by frequency

Drug Not Working

>10%

Fever

1-10%

Diarrhea

1-10%

Condition Worsened

1-10%

Shortness of Breath

0.1-1%

Rash

0.1-1%

Low Blood Pressure

0.1-1%

Nausea

0.1-1%

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Dosage Forms

Tablet

Route

Intravenous