What is PIROXICAM used for?

PIROXICAM (brand name Piroxicam) is a NSAID indicated for See full prescribing information.

What are the most common side effects of PIROXICAM?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for PIROXICAM. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is PIROXICAM the same as Piroxicam?

Piroxicam is a brand name for PIROXICAM. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

PIROXICAM

Q: How does PIROXICAM work?

PIROXICAM works through the following mechanism: 12.1 Mechanism of Action Piroxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of piroxicam capsules, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Piroxicam is a potent inhibitor of prostaglandin (PG) synthesis in vitro. Piroxicam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because piroxicam is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues..

NSAID

Brand names: Piroxicam

Oral

Mechanism of Action

12.1 Mechanism of Action Piroxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of piroxicam capsules, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Piroxicam is a potent inhibitor of prostaglandin (PG) synthesis in vitro. Piroxicam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because piroxicam is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS Piroxicam capsules are contraindicated in the following patients: • Known hypersensitivity (e.g.
• anaphylactic reactions and serious skin reactions) to piroxicam or any components of the drug product [see Warnings and Precautions (5.7
• 5.9) ] • History of asthma
• urticaria
• or other allergic-type reactions after taking aspirin or other NSAIDs. Severe

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Hepatotoxicity : Inform patients of warning signs and symptoms of hepatotoxicity
4 , 7 ) • Heart Failure and Edema : Avoid use of piroxicam capsules in patients with severe heart failure unless benefits are expected to outweigh risk of worsening heart failure ( 5
Avoid use of piroxicam capsules in patients with advanced renal disease unless benefits are expected to outweigh risk of worsening renal function ( 5
7 ) • Exacerbation of Asthma Related to Aspirin Sensitivity : Piroxicam capsules are contraindicated in patients with aspirin-sensitive asthma

Known Side Effects

8 documented side effects by frequency

Rash

1-10%

Joint Pain

1-10%

Condition Worsened

1-10%

Drug Not Working

1-10%

Diarrhea

1-10%

Fatigue

1-10%

Nausea

1-10%

Headache

1-10%

Community Discussions

No community discussions found for PIROXICAM yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → PIROXICAM openFDA label JSON → PIROXICAM FAERS adverse-event reports → PIROXICAM ClinicalTrials.gov → completed Phase 2+ trials of PIROXICAM

Compare With

15 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral