What is POSACONAZOLE used for?

POSACONAZOLE (brand name posaconazole) is a Antifungal indicated for See full prescribing information.

How does POSACONAZOLE work?

POSACONAZOLE works through the following mechanism: 12.1 Mechanism of Action Posaconazole is an azole antifungal agent [ see Clinical Pharmacology (12.4) ]..

What are the most common side effects of POSACONAZOLE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for POSACONAZOLE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is POSACONAZOLE the same as posaconazole?

posaconazole is a brand name for POSACONAZOLE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

POSACONAZOLE

Antifungal

Brand names: posaconazole

Oral

Mechanism of Action

12.1 Mechanism of Action Posaconazole is an azole antifungal agent [ see Clinical Pharmacology (12.4) ].

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS Known hypersensitivity to posaconazole or other azole antifungal agents. ( 4.1 ) Coadministration of posaconazole with the following drugs is contraindicated
• posaconazole increases concentrations and toxicities of: Sirolimus ( 4.2
• 5.1
• 7.1 ) CYP3A4 substrates (pimozide
• quinidine): can result in QTc interval prolongation and cases of torsades de pointes (TdP) ( 4.3

FDA Warnings

5 WARNINGS AND PRECAUTIONS Calcineurin-Inhibitor Toxicity : Posaconazole increases concentrations of cyclosporine or tacrolimus; reduce dose of cyclosporine and tacrolimus and monitor concentrations frequently
5 ) Vincristine Toxicity : Concomitant administration of azole antifungals, including posaconazole, with vincristine has been associated with neurotoxicity and other serious adverse reactions; reserve azole antifungals, including posaconazole, for patients receiving a vinca alkaloid, including vincristine, who have no alternative antifungal treatment options
10 ) Venetoclax Toxicity : Concomitant administration of posaconazole with venetoclax may increase venetoclax toxicities, including the risk of tumor lysis syndrome, neutropenia, and serious infections; monitor for toxicity and reduce venetoclax dose
Nephrotoxicity and leukoencephalopathy (including deaths) have been reported in clinical efficacy studies in patients with elevated cyclosporine or tacrolimus concentrations

Known Side Effects

5 documented side effects by frequency

Drug Not Working

>10%

Fever

1-10%

Diarrhea

0.1-1%

Nausea

0.1-1%

Condition Worsened

0.1-1%

Community Discussions

No community discussions found for POSACONAZOLE yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → POSACONAZOLE openFDA label JSON → POSACONAZOLE FAERS adverse-event reports → POSACONAZOLE ClinicalTrials.gov → completed Phase 2+ trials of POSACONAZOLE

Compare With

14 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral