POTASSIUM PHOSPHATES

Electrolyte / Mineral

Brand names: Potassium Phosphates

Intravenous

Mechanism of Action

12.1 Mechanism of Action Phosphorus in the form of organic and inorganic phosphate has a variety of biochemical functions in all organs and tissues, including critical roles in nucleic acid structure, energy storage and transfer, cell signaling, cell membrane composition and structure, acid-base balance, mineral homeostasis and bone mineralization.

Indications

insufficient or contraindicated. • for parenteral nutrition in adults and pediatric patients when oral or enteral nutrition is not possible

insufficient or contraindicated. ( 1 ) • for parenteral nutrition in adults and pediatric patients when oral or enteral nutrition is not possible

insufficient or contraindicated. ( 1 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Serious Cardiac Adverse Reactions with Undiluted, Bolus, or Rapid Intravenous Administration : Administer only after dilution or admixing; do not exceed the recommended infusion rate
2 ) • Hyperkalemia : Increased risk in patients with renal impairment, severe adrenal insufficiency, or treated with drugs that increase potassium
4 ) • Aluminum Toxicity : Increased risk in patients with renal impairment, including preterm infants
1 Serious Cardiac Adverse Reactions with Undiluted, Bolus or Rapid Intravenous Administration Intravenous administration of potassium phosphates to correct hypophosphatemia in single doses of phosphorus 50 mmol and greater and/or at rapid infusion rates (over 1 to 3 hours) in intravenous fluids has resulted in death, cardiac arrest, cardiac arrhythmia (including QT prolongation), hyperkalemia, hyperphosphatemia, and seizures [see Overdosage (10) ]

Known Side Effects

11 documented side effects by frequency

Nausea

1-10%

Fatigue

1-10%

Diarrhea

1-10%

Shortness of Breath

1-10%

Drug Not Working

1-10%

Vomiting

1-10%

Headache

1-10%

Dizziness

1-10%

Weakness

1-10%

Rash

0.1-1%

Joint Pain

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Intravenous