PRILOCAINE HCL AND EPINEPHRINE

Other

Pregnancy: Category BSubmucosal

Mechanism of Action

Mechanism of Action Prilocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action.

Indications

See full prescribing information

FDA Warnings

WARNINGS DENTAL PRACTITIONERS WHO EMPLOY LOCAL ANESTHETIC AGENTS SHOULD BE WELL VERSED IN DIAGNOSIS AND MANAGEMENT OF EMERGENCIES THAT MAY ARISE FROM THEIR USE
Although all patients are at risk for methemoglobinemia, patients with glucose-6-phosphate dehydrogenase deficiency, congenital or idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants under 6 months of age, and concurrent exposure to oxidizing agents or their metabolites are more susceptible to developing clinical manifestations of the condition
Methemoglobin levels may continue to rise; therefore, immediate treatment is required to avert more serious central nervous system and cardiovascular adverse effects, including seizures, coma, arrhythmias, and death

Known Side Effects

9 documented side effects by frequency

Fatigue

>10%

Nausea

>10%

Diarrhea

1-10%

Vomiting

1-10%

Fever

1-10%

Headache

1-10%

Shortness of Breath

1-10%

Drug Not Working

1-10%

Dizziness

0.1-1%

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Compare With

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Formulations

Dosage Forms

Tablet

Route

Submucosal