PROPOFOL

Other

Brand names: propofol

Intravenous

Mechanism of Action

12.1 Mechanism of Action The mechanism of action, like all general anesthetics, is poorly understood. However, propofol is thought to produce its sedative/anesthetic effects by the positive modulation of the inhibitory function of the neurotransmitter GABA through the ligand-gated GABA A receptors.

Indications

effectiveness and dosing guidelines for propofol injectable emulsion have not been established for MAC sedation in the pediatric population

therefore

Contraindications

• egg products
• soybeans or soy products. Known hypersensitivity to propofol
• egg or soybean ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Hypersensitivity Reactions : Serious and sometimes fatal reactions ( 5
1 Anaphylactic and Anaphylactoid Reactions Use of propofol injectable emulsion has been associated with both fatal and life threatening anaphylactic and anaphylactoid reactions
2 Risks of Microbial Contamination Strict aseptic technique must always be maintained during handling
There have been reports in which failure to use aseptic technique when handling propofol injectable emulsion was associated with microbial contamination of the product and with fever, infection/sepsis, other life-threatening illness, and/or death

Known Side Effects

4 documented side effects by frequency

Low Blood Pressure

>10%

Drug Not Working

>10%

Rapid Heart Rate

1-10%

Fever

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Intravenous