QUETIAPINE FUMARATE

Atypical Antipsychotic

Brand names: Quetiapine fumarate

Oral

Mechanism of Action

12.1 Mechanism of Action The mechanism of action of quetiapine in the listed indications is unclear. However, the efficacy of quetiapine in these indications could be mediated through a combination of dopamine type 2 (D 2 ) and serotonin type 2 (5HT 2 ) antagonism. The active metabolite, N-desalkyl quetiapine (norquetiapine), has similar activity at D 2 , but greater activity at 5HT 2A receptors, than the parent drug (quetiapine).

Indications

1 INDICATIONS AND USAGE Quetiapine tablet is an atypical antipsychotic indicated for the treatment of: Schizophrenia ( 1.1 ) Bipolar I disorder manic episodes ( 1.2 ) Bipolar disorder

both as monotherapy and as an adjunct to lithium or divalproex. Efficacy was established in two 12-week monotherapy trials in adults

in one 3-week adjunctive trial in adults

however

diagnosis can be challenging. For pediatric schizophrenia

symptom profiles can be variable

FDA Warnings

5 WARNINGS AND PRECAUTIONS Cerebrovascular Adverse Reactions: Increased incidence of cerebrovascular adverse reactions (e
Monitor glucose regularly in patients with diabetes or at risk for diabetes Dyslipidemia: Undesirable alterations have been observed in patients treated with atypical antipsychotics
1 Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death
Analysis of 17 placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1

Known Side Effects

9 documented side effects by frequency

Drug Not Working

1-10%

Insomnia

1-10%

Fatigue

1-10%

Weight Gain

1-10%

Drowsiness

1-10%

Nausea

1-10%

Depression

1-10%

Anxiety

1-10%

Dizziness

1-10%

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Formulations

Dosage Forms

Tablet

Route

Oral