RASBURICASE

Other

Brand names: Elitek

Oral

Mechanism of Action

12.1 Mechanism of Action In humans, uric acid is the final step in the catabolic pathway of purines. Rasburicase catalyzes enzymatic oxidation of poorly soluble uric acid into an inactive and more soluble metabolite (allantoin).

Indications

1 INDICATIONS AND USAGE Elitek is indicated for the initial management of plasma uric acid levels in pediatric and adult patients with leukemia

lymphoma

Contraindications

• Warnings and Precautions (5.1
• 5.2
• 5.3) ] . Elitek is contraindicated in individuals deficient in glucose-6-phosphate dehydrogenase (G6PD) [see Boxed Warning
• Warnings and Precautions (5.2) ] . History of the following reactions to rasburicase: anaphylaxis
• severe hypersensitivity

FDA Warnings

5 WARNINGS AND PRECAUTIONS 5
1 Hypersensitivity Reactions Elitek can cause serious and fatal hypersensitivity reactions including anaphylaxis
Immediately and permanently discontinue Elitek administration in any patient developing clinical evidence of a serious hypersensitivity reaction [see Boxed Warning , Contraindications (4) , Adverse Reactions (6
2 Hemolysis Elitek is contraindicated in patients with G6PD deficiency because hydrogen peroxide is one of the major by-products of the conversion of uric acid to allantoin

Known Side Effects

3 documented side effects by frequency

Fever

1-10%

Drug Not Working

1-10%

Low Blood Pressure

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral