RIBOFLAVIN 5-PHOSPHATE OPHTHALMIC

Electrolyte / Mineral

Brand names: EPIOXA CROSS-LINKING

Ophthalmic

Mechanism of Action

12.1 Mechanism of Action Riboflavin 5'-phosphate sodium (Vitamin B2) is the precursor of two coenzymes, flavin adenine dinucleotide and flavin mononucleotide, which catalyze oxidation/reduction reactions involved in a number of metabolic pathways. Under the conditions used for corneal collagen cross-linking, riboflavin 5'-phosphate functions as a photoenhancer and generates singlet oxygen which is responsible for the cross-linking.

Indications

1 INDICATIONS AND USAGE EPIOXA HD and EPIOXA are indicated in epithelium-on corneal collagen cross-linking for the treatment of keratoconus in adults and pediatric patients aged 13 years and older

in conjunction with the O 2 n System and the Boost Goggles ( 1 ).

FDA Warnings

5 WARNINGS AND PRECAUTIONS Herpetic keratitis : Use with caution in patients with a history of herpetic keratitis due to the potential for reactivation ( 5 )

Known Side Effects

13 documented side effects by frequency

Fatigue

>10%

Nausea

1-10%

Diarrhea

1-10%

Headache

1-10%

Drug Not Working

1-10%

Dizziness

1-10%

Shortness of Breath

1-10%

Joint Pain

1-10%

Weakness

1-10%

Falls

1-10%

Weight Loss

0.1-1%

Vomiting

0.1-1%

Limb Pain

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Ophthalmic