RIFAMPIN

Other

Brand names: Rifadin IV

Intravenous

Mechanism of Action

Mechanism of Action Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible Mycobacterium tuberculosis organisms. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.

Indications

INDICATIONS AND USAGE In the treatment of both tuberculosis and the meningococcal carrier state

the drug regimen should be modified. Tuberculosis Rifampin is indicated in the treatment of all forms of tuberculosis. A three-drug regimen consisting of rifampin

isoniazid

and pyrazinamide is recommended in the initial phase of short-course therapy which is usually continued for 2 months. The Advisory Council for the Elimination of Tuberculosis

the American Thoracic Society

and Centers for Disease Control and Prevention recommend that either streptomycin or ethambutol be added as a fourth drug in a regimen containing isoniazid (INH)

Contraindications

• CONTRAINDICATIONS RIFADIN is contraindicated in patients with a history of hypersensitivity to rifampin or any of the components
• Drug Interactions .) Rifampin is contraindicated in patients who are also receiving atazanavir
• darunavir
• fosamprenavir
• saquinavir

FDA Warnings

WARNINGS Hepatotoxicity of hepatocellular, cholestatic, and mixed patterns has been reported in patients treated with rifampin
Severity ranged from asymptomatic elevations in liver enzymes, isolated jaundice/hyperbilirubinemia, symptomatic self-limited hepatitis to fulminant liver failure and death
Severe hepatic dysfunction including fatalities were reported in patients with liver disease and in patients taking rifampin with other hepatotoxic agents
Monitor coagulation tests during rifampin treatment (prothrombin time and other coagulation tests) in patients at risk of vitamin K deficiency (such as those with chronic liver disease, poor nutritional status, on prolonged antibacterial drugs or anticoagulants)

Known Side Effects

8 documented side effects by frequency

Drug Not Working

>10%

Nausea

1-10%

Condition Worsened

1-10%

Fever

1-10%

Vomiting

0.1-1%

Shortness of Breath

0.1-1%

Rash

0.1-1%

Diarrhea

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Intravenous