RIFAPENTINE

Other

Brand names: Priftin

Oral

12.1 Mechanism of Action Rifapentine, a cyclopentyl rifamycin, is an antimycobacterial agent [see Microbiology (12.4) ] .

recent conversion to a positive tuberculin skin test

HIV-infected patients

Contraindications

• 4 CONTRAINDICATIONS Known hypersensitivity to any rifamycin. ( 4.1 ) 4.1 Hypersensitivity PRIFTIN is contraindicated in patients with a history of hypersensitivity to rifamycins.

5 WARNINGS AND PRECAUTIONS Hepatotoxicity: Monitor for symptoms of liver injury and discontinue PRIFTIN if signs or symptoms or liver injury occur
8 Clostridioides Difficile –Associated Diarrhea Clostridioides difficile –associated diarrhea (CDAD) has been reported with the use of nearly all systemic antibacterial agents, including PRIFTIN, with severity ranging from mild diarrhea to fatal colitis

11 documented side effects by frequency

Fever

>10%

Nausea

1-10%

High Blood Pressure

1-10%

Fatigue

1-10%

Vomiting

1-10%

Headache

1-10%

Rash

1-10%

Dizziness

1-10%

Shortness of Breath

1-10%

Low Blood Pressure

0.1-1%

Muscle Pain

0.1-1%

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Dosage Forms

Tablet

Route

Oral