RIVASTIGMINE TARTRATE

Alzheimer's Agent

Brand names: Rivastigmine Tartrate

Oral

Mechanism of Action

12.1 Mechanism of Action Although the precise mechanism of action of rivastigmine is unknown, it is thought to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by cholinesterase. Therefore, the effect of rivastigmine may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that rivastigmine alters the course of the underlying dementing process.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS Rivastigmine tartrate capsules are contraindicated in patients with: known hypersensitivity to rivastigmine
• other carbamate derivatives or other components of the formulation. (4) History of application site reaction with rivastigmine transdermal patch suggestive of allergic contact dermatitis
• in the absence of negative allergy testing (4
• 5.2)

FDA Warnings

5 WARNINGS AND PRECAUTIONS Gastrointestinal adverse reactions may include significant nausea, vomiting, diarrhea, anorexia/decreased appetite, and weight loss, and may necessitate treatment interruption
Dehydration may result from prolonged vomiting or diarrhea and can be associated with serious outcomes
Dehydration may result from prolonged vomiting or diarrhea and can be associated with serious outcomes
3)] to reduce the possibility of severe vomiting and its potentially serious sequelae (e

Known Side Effects

10 documented side effects by frequency

Falls

>10%

Drug Not Working

1-10%

Vomiting

1-10%

Nausea

1-10%

Dizziness

1-10%

General Unwellness

0.1-1%

Drowsiness

0.1-1%

Diarrhea

0.1-1%

Fatigue

0.1-1%

Weakness

0.1-1%

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Compare With

8 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral