RIZATRIPTAN BENZOATE

Triptan (Migraine)

Brand names: MAXALT, MAXALT-MLT

Oral

Mechanism of Action

12.1 Mechanism of Action Rizatriptan binds with high affinity to human cloned 5-HT 1B/1D receptors. MAXALT presumably exerts its therapeutic effects in the treatment of migraine headache by binding to 5-HT 1B/1D receptors located on intracranial blood vessels and sensory nerves of the trigeminal system.

Indications

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Contraindications

• 4 CONTRAINDICATIONS MAXALT is contraindicated in patients with: Ischemic coronary artery disease (angina pectoris
• history of myocardial infarction
• or documented silent ischemia)
• within 24 hours) of another 5-HT 1 agonist
• ergotamine-containing medication

FDA Warnings

5 WARNINGS AND PRECAUTIONS Myocardial ischemia, myocardial infarction, and Prinzmetal's angina: Perform cardiac evaluation in patients with multiple cardiovascular risk factors ( 5
2 ) Chest/throat/neck/jaw pain, tightness, pressure, or heaviness; Generally not associated with myocardial ischemia; Evaluate patients at high risk ( 5
There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a few hours following administration of MAXALT
Triptan-naïve patients who have multiple cardiovascular risk factors (e

Known Side Effects

11 documented side effects by frequency

Drug Not Working

>10%

Nausea

>10%

Headache

>10%

Fatigue

1-10%

Vomiting

1-10%

Dizziness

0.1-1%

Diarrhea

0.1-1%

Shortness of Breath

0.1-1%

Joint Pain

0.1-1%

Anxiety

0.1-1%

Excessive Sweating

0.1-1%

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Compare With

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Formulations

Dosage Forms

Tablet

Route

Oral