ROPINIROLE

Parkinson's Agent

Brand names: ropinirole, Requip

Oral

Mechanism of Action

12.1 Mechanism of Action Ropinirole is a non-ergoline dopamine agonist. The precise mechanism of action of ropinirole as a treatment for Parkinson’s disease is unknown, although it is thought to be related to its ability to stimulate dopamine D 2 receptors within the caudate-putamen in the brain. The precise mechanism of action of ropinirole as a treatment for RLS is unknown, although it is thought to be related to its ability to stimulate dopamine receptors.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS Ropinirole tablets are contraindicated in patients known to have a hypersensitivity/allergic reaction (including urticaria
• angioedema
• rash
• pruritus) to ropinirole or to any of the excipients. History of hypersensitivity/allergic reaction (including urticaria
• angioedema

FDA Warnings

5 WARNINGS AND PRECAUTIONS Sudden onset of sleep and somnolence may occur ( 5
Although many of these patients reported somnolence while on ropinirole, some perceived that they had no warning signs, such as excessive drowsiness, and believed that they were alert immediately prior to the event
Before initiating treatment with ropinirole, patients should be advised of the potential to develop drowsiness and specifically asked about factors that may increase the risk with ropinirole such as concomitant sedating medications or alcohol, the presence of sleep disorders (other than RLS), and concomitant medications that increase ropinirole plasma levels (e
Patients on ropinirole should be monitored for signs and symptoms of orthostatic hypotension, especially during dose escalation, and should be informed of the risk for syncope and hypotension [ see Patient Counseling Information ( 17 )]

Known Side Effects

10 documented side effects by frequency

Drug Not Working

>10%

Falls

1-10%

Fatigue

1-10%

Nausea

1-10%

Dizziness

1-10%

Shortness of Breath

1-10%

Diarrhea

1-10%

Weakness

1-10%

Headache

1-10%

Insomnia

1-10%

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Compare With

11 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral