ROSUVASTATIN CALCIUM

Electrolyte / Mineral

Brand names: Rosuvastatin Calcium

Oral

Mechanism of Action

12.1 Mechanism of Action Rosuvastatin is an inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3‑hydroxy‑3‑methylglutaryl coenzyme A to mevalonate, a precursor of cholesterol.

Indications

1 INDICATIONS AND USAGE Rosuvastatin tablets is indicated: To reduce the risk major adverse cardiovascular (CV) events (CV death

nonfatal myocardial infarction

nonfatal stroke

or an arterial revascularization procedure) in adults without established coronary heart disease who are at increased risk of CV disease based on age

high-sensitivity C-reactive protein (hsCRP) ≥2 mg/L

or alone if such treatments are unavailable

Contraindications

• pruritus
• urticaria

FDA Warnings

5 WARNINGS AND PRECAUTIONS Myopathy and Rhabdomyolysis : Risk factors include age 65 years or greater, uncontrolled hypothyroidism, renal impairment, concomitant use with certain other drugs, and higher rosuvastatin dosage
Asian patients may be at higher risk for myopathy
Temporarily discontinue rosuvastatin in patients experiencing an acute or serious condition at high risk of developing renal failure secondary to rhabdomyolysis
Inform patients of the risk of myopathy and rhabdomyolysis when starting or increasing rosuvastatin dosage

Known Side Effects

13 documented side effects by frequency

Fatigue

1-10%

Nausea

1-10%

Shortness of Breath

1-10%

Drug Not Working

1-10%

Diarrhea

1-10%

Muscle Pain

1-10%

Headache

1-10%

Dizziness

1-10%

Joint Pain

1-10%

Weakness

1-10%

Limb Pain

1-10%

General Unwellness

1-10%

Falls

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral