SELENIOUS ACID

Other

Brand names: Selenious Acid

Intravenous

Mechanism of Action

12.1 Mechanism of Action Selenious acid is converted in vivo to hydrogen selenide via glutathione-involved electron reductions. Hydrogen selenide acts as a selenium pool to form selenoproteins which include, but are not limited to, glutathione peroxidase, iodothyronine deiodinase, peroxidase and thioredoxins.

Indications

1 INDICATIONS AND USAGE Selenious Acid Injection is indicated in adult and pediatric patients as a source of selenium for parenteral nutrition when oral or enteral nutrition is not possible

insufficient

or contraindicated.

Contraindications

• 4 CONTRAINDICATIONS None. None.

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Pulmonary Embolism due to Pulmonary Vascular Precipitates: If signs of pulmonary distress occur, stop the infusion and initiate a medical evaluation
2 ) • Aluminum Toxicity : Increased risk in patients with renal impairment, including preterm infants
The cause of precipitate formation has not been determined in all cases; however, in some fatal cases, pulmonary emboli occurred as a result of calcium phosphate precipitates
Preterm infants are particularly at risk for aluminum toxicity because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which also contain aluminum

Known Side Effects

3 documented side effects by frequency

Diarrhea

1-10%

Fatigue

1-10%

Nausea

1-10%

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Formulations

Dosage Forms

Tablet

Route

Intravenous