SEVELAMER CARBONATE

Other

Brand names: Sevelamer Carbonate

Oral

Mechanism of Action

12.1 Mechanism of Action Sevelamer carbonate tablet contains sevelamer carbonate, a non-absorbed phosphate-binding cross-linked polymer, free of metal and calcium. It contains multiple amines separated by one carbon from the polymer backbone. These amines exist in a protonated form in the intestine and interact with phosphate molecules through ionic and hydrogen bonding. By binding phosphate in the gastrointestinal tract and decreasing absorption, sevelamer carbonate lowers the phosphate concentration in the serum (serum phosphorus).

Indications

See full prescribing information

Contraindications

• sevelamer hydrochloride
• or to any of the excipients. Bowel obstruction. ( 4 ) Known hypersensitivity to sevelamer carbonate
• sevelamer hydrochloride
• or to any of the excipients. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Serious cases of dysphagia, bowel obstruction, bleeding gastrointestinal ulcers, colitis, ulceration, necrosis, and perforation have been associated with sevelamer use, some requiring hospitalization and surgery

Known Side Effects

8 documented side effects by frequency

Constipation

>10%

Diarrhea

1-10%

Itching

1-10%

Nausea

1-10%

Vomiting

1-10%

Abdominal Pain

0.1-1%

Shortness of Breath

0.1-1%

Fatigue

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral