SODIUM IODIDE I-131

Electrolyte / Mineral

Brand names: Sodium Iodide I-131

Oral

Mechanism of Action

12.1 Mechanism of Action Iodide is actively transported by the sodium-iodide symporter (NIS) protein, in thyroid follicular cells. Iodide is concentrated in follicular cells to levels up to 50 times higher than in the plasma. Iodide is metabolically oxidized by thyroid peroxidase to iodinium (I + ) which in turn iodinates tyrosine residues of thyroglobulin (tri or tetra-iodinated tyrosine). The beta emission of I 131 is responsible for the therapeutic effect.

Indications

See full prescribing information

FDA Warnings

5 WARNINGS AND PRECAUTIONS Radiation-induced thyroiditis may cause or worsen hyperthyroidism
Consider a beta-blocker pre or post-treatment to minimize the risk of hyperthyroidism and thyroid storm
2 Radiation-induced Toxicities Sodium Iodide I 131 may cause radiation induced toxicities [see Adverse Reactions (6) ] : Dose-dependent fatalities (bone marrow suppression, malignancy)
Increased risk of developing new solid tumors and leukemias

Known Side Effects

12 documented side effects by frequency

Drug Not Working

>10%

Fatigue

1-10%

Nausea

1-10%

Headache

1-10%

Shortness of Breath

1-10%

Diarrhea

1-10%

Joint Pain

1-10%

Vomiting

1-10%

Dizziness

0.1-1%

Rash

0.1-1%

Fever

0.1-1%

General Unwellness

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral