SOLIFENACIN SUCCINATE

Other

Brand names: solifenacin succinate, Vesicare

Oral

Mechanism of Action

12.1 Mechanism of Action Solifenacin is a competitive muscarinic receptor antagonist. Muscarinic receptors play an important role in several major cholinergically mediated functions, including contractions of urinary bladder smooth muscle.

Indications

1 INDICATIONS AND USAGE Solifenacin succinate tablets are indicated for the treatment of adults with overactive bladder with symptoms of urge urinary incontinence

urgency

and urinary frequency. Solifenacin succinate tablets are a muscarinic antagonist indicated for the treatment of adults with overactive bladder with symptoms of urge urinary incontinence

urgency

and urinary frequency ( 1 ).

Contraindications

• 4 CONTRAINDICATIONS Solifenacin succinate tablets are contraindicated in patients: • With urinary retention [ see Warnings and Precautions ( 5.2 ) ]
• • With gastric retention [ see Warnings and Precautions ( 5.3 ) ]
• • With uncontrolled narrow-angle glaucoma [ see Warnings and Precautions ( 5.5 ) ]
• 5.2 ). • Gastric retention ( 4
• 5.3 ). • Uncontrolled narrow-angle glaucoma ( 4

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Angioedema and Anaphylactic Reactions : Promptly discontinue solifenacin succinate and provide appropriate therapy ( 5
• QT Prolongation in Patients at High Risk of QT Prolongation : Solifenacin succinate is not recommended for use in patients at high risk of QT prolongation, including patients with a known history of QT prolongation and patients taking medications known to prolong the QT interval ( 5
Solifenacin succinate is contraindicated in patients with a known or suspected hypersensitivity to solifenacin succinate [ see Contraindications ( 4 ) ]
The use of solifenacin succinate is not recommended in patients with clinically significant bladder outlet obstruction and is contraindicated in patients with urinary retention [ see Contraindications ( 4 ) ]

Known Side Effects

13 documented side effects by frequency

Drug Not Working

>10%

Dry Mouth

1-10%

Constipation

1-10%

Fatigue

1-10%

Falls

1-10%

Dizziness

1-10%

Nausea

1-10%

Headache

0.1-1%

Blurred Vision

0.1-1%

UTI

0.1-1%

Diarrhea

0.1-1%

Weakness

0.1-1%

General Unwellness

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral