SOYBEAN OIL

Other

Brand names: NutriLipid I.V. Fat Emulsion

Intravenous

Mechanism of Action

12.1 Mechanism of Action Nutrilipid 20% administered intravenously provides biologically utilizable source of calories and essential fatty acids. Fatty acids serve as an important substrate for energy production. The most common mechanism of action for energy production derived from fatty acid metabolism is beta oxidation. Fatty acids are important for membrane structure and function, precursors for bioactive molecules (such as prostaglandins), and as regulators of gene expression. Nutrilipid 20% causes an increase in heat production, decrease in respiratory quotient, and increase in oxygen consumption following its administration.

Indications

insufficient

or contraindicated. ( 1 )

Contraindications

• 4 CONTRAINDICATIONS Nutrilipid 20% injection is contraindicated in patients who have: Known hypersensitivity to egg
• soybean
• peanut
• or any of the active or inactive ingredients in Nutrilipid 20% [see Warnings and Precautions (5.3) ]. Severe disorders of lipid metabolism characterized by hypertriglyceridemia (serum triglyceride >1
• 000 mg/dL) [see Warnings and Precautions (5.7) ]. Known hypersensitivity to egg

FDA Warnings

5 WARNINGS AND PRECAUTIONS Clinical Decompensation with Rapid Infusion of Intravenous Lipid Emulsion in Neonates and Infants : Acute respiratory distress, metabolic acidosis, and death after rapid infusion of intravenous lipid emulsions have been reported
4 ) Parenteral Nutrition-Associated Liver Disease : Increased risk in patients who receive parenteral nutrition for greater than 2 weeks, especially preterm neonates
7 ) Aluminum Toxicity : Increased risk in patients with renal impairment, including preterm neonates
1 Clinical Decompensation with Rapid Infusion of Intravenous Lipid Emulsion in Neonates and Infants In the postmarketing setting, serious adverse reactions including acute respiratory distress, metabolic acidosis, and death have been reported in neonates and infants after rapid infusion of intravenous lipid emulsions

Known Side Effects

10 documented side effects by frequency

Fever

>10%

Nausea

>10%

Vomiting

1-10%

Shortness of Breath

1-10%

Heart Palpitations

1-10%

Itching

0.1-1%

Rash

0.1-1%

Abdominal Pain

0.1-1%

Dizziness

0.1-1%

Weakness

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Intravenous