SUFENTANIL CITRATE

Other

Brand names: Sufentanil Citrate

Epidural, Intravenous

Mechanism of Action

12.1 Mechanism of Action Sufentanil is an opioid agonist. When used in balanced general anesthesia, sufentanil has been reported to be as much as 10 times as potent as fentanyl. When administered intravenously as a primary anesthetic agent with 100% oxygen, sufentanil is approximately 5 to 7 times as potent as fentanyl.

Indications

in patients who are intubated and ventilated

such as cardiovascular surgery or neurosurgical procedures in the sitting position

in patients who are intubated and ventilated

such as cardiovascular surgery or neurosurgical procedures in the sitting position

Contraindications

• 4 CONTRAINDICATIONS Sufentanil Citrate Injection is contraindicated in patients with: • Hypersensitivity to sufentanil (e.g.
• anaphylaxis) [see Adverse Reactions (6.2) ] • Hypersensitivity to sufentanil. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Life-Threatening Respiratory Depression in Patients with Chronic Pulmonary Disease or in Elderly, Cachectic, or Debilitated Patients : Monitor closely, particularly during initiation and titration
2 ) • Risks of Skeletal Muscle Rigidity and Skeletal Muscle Movement : Manage with neuromuscular blocking agent
See full prescribing information for more detail on managing these risks
8 ) • Risks of Use in Patients with Increased Intracranial Pressure, Brain Tumors, or Head Injury : Monitor for sedation and respiratory depression

Known Side Effects

4 documented side effects by frequency

Low Blood Pressure

>10%

Drug Not Working

1-10%

Rapid Heart Rate

1-10%

Rash

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Epidural, Intravenous