SULINDAC

Other

Brand names: SULINDAC

Oral

Mechanism of Action

Pharmacodynamics Sulindac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic activities in animal models. The mechanism of action, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition.

Indications

largely or wholly bedridden

or confined to wheelchair

little or no self-care).

Contraindications

• urticaria
• or allergic-type reactions after taking aspirin or other NSAIDs. Severe
• rarely fatal
• anaphylactic/anaphylactoid reactions to NSAIDs have been reported in such patients (see WARNINGS – Anaphylactic/Anaphylactoid Reactions
• and PRECAUTIONS – Preexisting Asthma ). Sulindac is contraindicated in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS ).

FDA Warnings

Cardiovascular Thrombotic Events • Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal
This risk may occur early in treatment and may increase with duration of use (see WARNINGS and PRECAUTIONS )
• Sulindac tablets are contraindicated in the setting of coronary artery bypass graft (CABG) surgery (see CONTRAINDICATIONS and WARNINGS )
Gastrointestinal Risk • NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal

Known Side Effects

13 documented side effects by frequency

Drug Not Working

>10%

Fatigue

1-10%

Joint Pain

1-10%

Nausea

1-10%

Limb Pain

1-10%

Weakness

1-10%

Diarrhea

1-10%

Headache

1-10%

Back Pain

1-10%

Shortness of Breath

1-10%

Dizziness

0.1-1%

Itching

0.1-1%

Falls

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Oral