TAMOXIFEN CITRATE

SERM

Brand names: SOLTAMOX, Nolvadex

Oral

Mechanism of Action

12.1 Mechanism of Action Tamoxifen is an estrogen agonist/antagonist. Tamoxifen competes with estrogen for binding to the estrogen receptor, which can result in a decrease in estrogen receptor signaling-dependent growth in breast tissue. Tamoxifen has demonstrated antitumor activity against human breast cancer cell lines xenografted in mice. The drug has been shown to inhibit the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA) and to cause the regression of already established DMBA-induced tumors.

Indications

following breast surgery and radiation

Contraindications

• 4 CONTRAINDICATIONS SOLTAMOX is contraindicated in patients with known hypersensitivity (e.g.
• angioedema
• if the indication for treatment is either reduction of breast cancer incidence in high-risk patients or risk reduction of invasive breast cancer after treatment of DCIS ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Uterine malignancies: Promptly evaluate abnormal vaginal bleeding in a woman with current or past tamoxifen use
1 ) Thromboembolic events: Risk increases with coadministered chemotherapy
For treatment of breast cancer, consider risks and benefits in patients with a history of thromboembolic events
Advise females of reproductive potential of the potential risk to a fetus and to use effective contraception

Known Side Effects

10 documented side effects by frequency

Fatigue

>10%

Nausea

1-10%

Joint Pain

1-10%

Diarrhea

1-10%

Vomiting

1-10%

Shortness of Breath

1-10%

Dizziness

1-10%

Headache

1-10%

Drug Not Working

1-10%

Weakness

1-10%

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Compare With

3 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral