TAZAROTENE

Other

Brand names: TAZORAC

Cutaneous

Mechanism of Action

12.1 Mechanism of Action Tazarotene is a retinoid prodrug which is converted to its active form, the carboxylic acid of tazarotene, by deesterification. Tazarotenic acid binds to all three members of the retinoic acid receptor (RAR) family: RARα, RARβ, and RARɣ, but shows relative selectivity for RARβ, and RARɣ and may modify gene expression. The clinical significance of these findings is unknown.

Indications

0.05% and 0.1% are indicated for the topical treatment of patients with plaque psoriasis. 1.2 Acne Vulgaris TAZORAC (tazarotene) Cream

0.1% is also indicated for the topical treatment of patients with acne vulgaris.

Contraindications

• 4 CONTRAINDICATIONS TAZORAC Cream is contraindicated in: Pregnancy. Retinoids may cause fetal harm when administered to a pregnant female [see Warnings and Precautions ( 5.1 )
• Use in Specific Populations ( 8.1
• 8.3 )] . Individuals who have known hypersensitivity to any of its components [see Warnings and Precautions ( 5.2 )] . Pregnancy ( 4
• 8.1 ) Hypersensitivity ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Embryofetal Toxicity: TAZORAC Cream contains tazarotene, which is a teratogenic substance
TAZORAC Cream is contraindicated in pregnancy
2 ) Photosensitivity and Risk for Sunburn: Avoid exposure to sunlight, sunlamps, and weather extremes
Females of Child-bearing Potential Females of child-bearing potential should be warned of the potential risk and use adequate birth-control measures when TAZORAC Cream is used

Known Side Effects

6 documented side effects by frequency

Drug Not Working

>10%

Itching

1-10%

Rash

1-10%

Headache

1-10%

Diarrhea

0.1-1%

Nausea

0.1-1%

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Formulations

Dosage Forms

Tablet

Route

Cutaneous