TELMISARTAN AND AMLODIPINE

ARB

Brand names: Telmisartan and Amlodipine

Pregnancy: Category DOral

Mechanism of Action

12.1 Mechanism of Action Telmisartan Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT 1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis. There is also an AT 2 receptor found in many tissues, but AT 2 is not known to be associated with cardiovascular homeostasis. Telmisartan has much greater affinity (>3,000 fold) for the AT 1 receptor than for the AT 2 receptor. Blockade of the renin-angiotensin system with ACE inhibitors, wh

Indications

1 INDICATIONS AND USAGE Telmisartan and amlodipine tablets are indicated for the treatment of hypertension

alone or with other antihypertensive agents to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events

including

as appropriate

lipid control

diabetes management

Contraindications

• 4 CONTRAINDICATIONS Telmisartan and amlodipine tablets are contraindicated in patients with known hypersensitivity (e.g.
• anaphylaxis or angioedema) to telmisartan
• amlodipine
• anaphylaxis or angioedema) to telmisartan
• amlodipine or any other component of this product (4) Do not co-administer aliskiren with telmisartan and amlodipine tablets in patients with diabetes (4)

FDA Warnings

5 WARNINGS AND PRECAUTIONS Avoid fetal or neonatal exposure (5
1 Fetal Toxicity Pregnancy Category D Telmisartan Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death
Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death
Consider periodic determinations of serum electrolytes to detect possible electrolyte imbalances, particularly in patients at risk

Known Side Effects

13 documented side effects by frequency

Nausea

1-10%

Fatigue

1-10%

Drug Not Working

1-10%

Diarrhea

1-10%

Shortness of Breath

1-10%

Headache

1-10%

Dizziness

1-10%

Falls

1-10%

High Blood Pressure

1-10%

Joint Pain

1-10%

General Unwellness

1-10%

Weakness

1-10%

Vomiting

1-10%

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Compare With

13 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral