THIORIDAZINE HYDROCHLORIDE

Typical Antipsychotic

Brand names: Thioridazine Hydrochloride

Oral

Mechanism of Action

Other agent

Indications

potentially life threatening

proarrhythmic effects with thioridazine treatment

thioridazine hydrochloride tablets should be used only in patients who have failed to respond adequately to treatment with appropriate courses of other antipsychotic drugs

either because of insufficient effectiveness or the inability to achieve an effective dose due to intolerable adverse effects from those drugs. Consequently

before initiating treatment with thioridazine hydrochloride tablets

it is strongly recommended that a patient be given at least two trials

Contraindications

• fluoxetine and paroxetine) and certain other drugs (e.g.
• fluvoxamine
• propranolol
• potentially fatal
• cardiac arrhythmias

FDA Warnings

WARNING Thioridazine has been shown to prolong the QTc interval in a dose related manner, and drugs with this potential, including thioridazine, have been associated with Torsades de pointes type arrhythmias and sudden death
Due to its potential for significant, possibly life threatening, proarrhythmic effects, thioridazine should be reserved for use in the treatment of schizophrenic patients who fail to show an acceptable response to adequate courses of treatment with other antipsychotic drugs, either because of insufficient effectiveness or the inability to achieve an effective dose due to intolerable adverse effects from those drugs (see WARNINGS , CONTRAINDICATIONS , and INDICATIONS )
Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death
Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1

Known Side Effects

7 documented side effects by frequency

Weight Gain

1-10%

Drug Not Working

1-10%

Shortness of Breath

1-10%

General Unwellness

1-10%

Itching

1-10%

Ringing in Ears

1-10%

Abdominal Pain

1-10%

Community Discussions

No community discussions found for THIORIDAZINE HYDROCHLORIDE yet.

Compare With

10 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral