TIPRANAVIR

Other

Brand names: Aptivus

Oral

12.1 Mechanism of Action Tipranavir is an antiretroviral drug [ see Microbiology (12.4) ].

1 INDICATIONS AND USAGE APTIVUS

co-administered with ritonavir

3-class antiretroviral (NRTI

NNRTI

a protease inhibitor

co-administered with ritonavir

Contraindications

• 4 CONTRAINDICATIONS APTIVUS is contraindicated in patients with moderate or severe (Child-Pugh Class B or C
• bepridil
• flecainide
• propafenone
• ergonovine

5 WARNINGS AND PRECAUTIONS Co-administration with Ritonavir: APTIVUS must be co-administered with ritonavir and food to achieve the desired antiviral effect
2 ) Intracranial Hemorrhage/Platelet Aggregation and Coagulation: Use with caution in patients at risk for increased bleeding or who are receiving medications that increase the risk of bleeding
2 Hepatic Impairment and Toxicity Clinical hepatitis and hepatic decompensation, including some fatalities, were reported with APTIVUS co-administered with 200 mg of ritonavir
All patients should be followed closely with clinical and laboratory monitoring, especially those with chronic hepatitis B or C co-infection, as these patients have an increased risk of hepatotoxicity

4 documented side effects by frequency

Nausea

1-10%

Vomiting

1-10%

Condition Worsened

1-10%

Peripheral Edema

0.1-1%

No community discussions found for TIPRANAVIR yet.

0 available comparisons

No comparisons yet.

Dosage Forms

Tablet

Route

Oral