TIZANIDINE

Other

Brand names: tizanidine

Oral

Mechanism of Action

Other agent

Indications

1 INDICATIONS AND USAGE Tizanidine is indicated for the treatment of spasticity in adults. Tizanidine is a central alpha-2-adrenergic agonist indicated for the treatment of spasticity. (1)

Contraindications

• 7.1 ) Patients with a history of hypersensitivity to tizanidine or the ingredients in tizanidine tablets ( 4
• 5.5 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Hypotension: monitor for signs and symptoms of hypotension, in particular in patients receiving concurrent antihypertensives; tizanidine should not be used with other α 2 -adrenergic agonists ( 5
5 ) Risk of liver injury: monitor ALTs; discontinue tizanidine if liver injury occurs ( 5
The risk of hypotension may be minimized by dose titration; monitoring for signs and symptoms of hypotension prior to dosage increase may minimize the risks associated with hypotension
In addition, patients moving from a supine to fixed upright position may be at increased risk for hypotension and orthostatic effects

Known Side Effects

13 documented side effects by frequency

Fatigue

>10%

Nausea

1-10%

Drug Not Working

1-10%

Headache

1-10%

Falls

1-10%

Diarrhea

1-10%

Dizziness

1-10%

Shortness of Breath

1-10%

Joint Pain

1-10%

Vomiting

0.1-1%

Weakness

0.1-1%

Depression

0.1-1%

Anxiety

0.1-1%

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Compare With

11 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral