TIZANIDNE HYDROCHLORIDE

Electrolyte / Mineral

Brand names: Tizanidne hydrochloride

Oral

Mechanism of Action

12.1 Mechanism of Action Tizanidine is a central alpha-2-adrenergic receptor agonist and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons.

Indications

1 INDICATIONS AND USAGE Tizanidine hydrochloride is indicated for the management of spasticity. Because of the short duration of therapeutic effect

treatment with tizanidine hydrochloride capsules should be reserved for those daily activities and times when relief of spasticity is most important. ( 1 )

Contraindications

• 4 CONTRAINDICATIONS Tizanidine hydrochloride capsules is contraindicated in patients taking potent inhibitors of CYP1A2
• such as fluvoxamine or ciprofloxacin [see Drug Interactions ( 7.1
• 7.2 )]. Concomitant use with potent inhibitors of CYP1A2
• such as fluvoxamine or ciprofloxacin( 4
• 5.5

FDA Warnings

5 WARNINGS AND PRECAUTIONS Hypotension: monitor for signs and symptoms of hypotension, in particular in patients receiving concurrent antihypertensives; tizanidine should not be used with other α2-adrenergic agonists ( 5
7 ) Risk of liver injury: monitor ALTs; discontinue tizanidine if liver injury occurs ( 5
In addition, patients moving from a supine to fixed upright position may be at increased risk for hypotension and orthostatic effects
Therefore, concomitant use of tizanidine with fluvoxamine or with ciprofloxacin, potent inhibitors of CYP1A2, is contraindicated [see Contraindications ( 4 ) and Drug Interactions ( 7

Known Side Effects

0 documented side effects by frequency

No structured side effect data available.

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Formulations

Dosage Forms

Tablet

Route

Oral