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DrugNote

TRADIPITANT

Other

Brand names: NEREUS

Oral

Mechanism of Action

12.1 Mechanism of Action Tradipitant is a selective, high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Tradipitant does not have affinity for NK2 and NK3 receptors, serotonin (5-HT3), dopamine (D2), cholinergic, or histamine (H1) receptors. Tradipitant has been shown in animal models to inhibit drug induced emesis. Human Positron Emission Tomography (PET) studies with tradipitant have shown that tradipitant crosses the blood brain barrier and occupies brain NK-1 receptors. The exact mechanism by which tradipitant exerts its therapeutic effect is not fully established.

Indications

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Contraindications

  • • 4 CONTRAINDICATIONS None. None. ( 4 )

FDA Warnings

  • 5 WARNINGS AND PRECAUTIONS Effects on the Ability to Drive or Operate Machinery: May impair mental and/or physical abilities required for driving a motor vehicle or operating heavy machinery

Known Side Effects

0 documented side effects by frequency

No structured side effect data available.

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Formulations

Dosage Forms

Tablet

Route

Oral